Background: Diffuse reflection imaging could potentially be used to recover the\nsuperficial microvasculature under cutaneous tissue and the associated blood oxygenation\nstatus with a modified imaging resolution. The aim of this work is to deliver\na new approach of local off-axis scanning diffuse reflection imaging, with the revisit of\nthe modified Beerââ?¬â??Lambert Law (MBLL).\nMethods: To validate this, the system is used to recover the micron-scale subsurface\nvessel structure interiorly embedded in a skin equivalent tissue phantom. This vessel\nstructure is perfused with oxygenated meta-hemoglobin solution.\nResults: Our preliminary results confirm that the thin vessel structure can be mapped\ninto a 2-D planar image. The distributions of oxygenated hemoglobin concentration\n(CtHbO2) and deoxygenated hemoglobin concentration (CtRHb) can be co-registerated\nthrough the MBLL upon the CW spectroscopy, the scattering issue is addressed in the\nreformed MBLL. The recovered pattern matches to the estimation from the simultaneous\noptical coherence tomography studies.\nConclusions: With further modification, this system may serve as the first prototype\nto investigate the superficial microvasculature in the expot ential skin cancer loci, or a\nmicro-lesion of vascular dermatosis.
Loading....